from pathlib import Path
import pandas as pd
from immuneML.data_model.dataset.RepertoireDataset import RepertoireDataset
from immuneML.data_model.encoded_data.EncodedData import EncodedData
from immuneML.encodings.DatasetEncoder import DatasetEncoder
from immuneML.encodings.EncoderParams import EncoderParams
from immuneML.util.PathBuilder import PathBuilder
[docs]class DeepRCEncoder(DatasetEncoder):
"""
DeepRCEncoder should be used in combination with the DeepRC ML method (:ref:`DeepRC`).
This encoder writes the data in a RepertoireDataset to .tsv files.
For each repertoire, one .tsv file is created containing the amino acid sequences and the counts.
Additionally, one metadata .tsv file is created, which describes the subset of repertoires that is encoded by
a given instance of the DeepRCEncoder.
Note: sequences where count is None, the count value will be set to 1
YAML specification:
.. indent with spaces
.. code-block:: yaml
my_deeprc_encoder: DeepRC
"""
ID_COLUMN = "ID"
SEQUENCE_COLUMN = "amino_acid"
COUNTS_COLUMN = "templates"
SEP = "\t"
EXTENSION = "tsv"
def __init__(self, context: dict = None, name: str = None):
self.context = context
self.name = name
self.max_sequence_length = 0
[docs] def set_context(self, context: dict):
self.context = context
return self
@staticmethod
def _prepare_parameters(context: dict = None, name: str = None):
return {"context": context,
"name": name}
[docs] @staticmethod
def build_object(dataset, **params):
if isinstance(dataset, RepertoireDataset):
prepared_params = DeepRCEncoder._prepare_parameters(**params)
return DeepRCEncoder(**prepared_params)
else:
raise ValueError("DeepRCEncoder is not defined for dataset types which are not RepertoireDataset.")
[docs] def export_repertoire_tsv_files(self, output_folder: Path):
repertoires = self.context["dataset"].repertoires
for repertoire in repertoires:
filepath = output_folder / f"{repertoire.identifier}.{DeepRCEncoder.EXTENSION}"
if not filepath.is_file():
df = pd.DataFrame({DeepRCEncoder.SEQUENCE_COLUMN: repertoire.get_sequence_aas(), DeepRCEncoder.COUNTS_COLUMN: repertoire.get_counts()})
df[DeepRCEncoder.COUNTS_COLUMN].fillna(1, inplace=True)
df.to_csv(path_or_buf=filepath, sep=DeepRCEncoder.SEP, index=False)
max_sequence_length = max(df[DeepRCEncoder.SEQUENCE_COLUMN].str.len())
self.max_sequence_length = max(self.max_sequence_length, max_sequence_length)
[docs] def encode(self, dataset, params: EncoderParams) -> RepertoireDataset:
result_path = params.result_path / "encoding"
PathBuilder.build(result_path)
self.export_repertoire_tsv_files(result_path)
labels = params.label_config.get_labels_by_name()
metadata_filepath = self.export_metadata_file(dataset, labels, result_path)
encoded_dataset = dataset.clone()
encoded_dataset.encoded_data = EncodedData(examples=None, labels=dataset.get_metadata(labels) if params.encode_labels else None,
example_ids=dataset.repertoire_ids,
encoding=DeepRCEncoder.__name__,
info={"metadata_filepath": metadata_filepath,
"max_sequence_length": self.max_sequence_length})
return encoded_dataset
[docs] @staticmethod
def export_encoder(path: Path, encoder) -> Path:
encoder_file = DatasetEncoder.store_encoder(encoder, path / "encoder.pickle")
return encoder_file